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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:definition>999062 - Disclosure - SCHEDULE OF LONG TERM DEBT (Details) (Parenthetical)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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        </link:roleType>
        <link:roleType roleURI="http://harrow.com/role/ScheduleOfFutureMinimumPaymentUnderNotesPayablesDetails" id="ScheduleOfFutureMinimumPaymentUnderNotesPayablesDetails">
          <link:definition>999063 - Disclosure - SCHEDULE OF FUTURE MINIMUM PAYMENT UNDER NOTES PAYABLES (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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        <link:roleType roleURI="http://harrow.com/role/DebtDetailsNarrative" id="DebtDetailsNarrative">
          <link:definition>999064 - Disclosure - DEBT (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://harrow.com/role/LeasesDetailsNarrative" id="LeasesDetailsNarrative">
          <link:definition>999065 - Disclosure - LEASES (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://harrow.com/role/ScheduleOfFutureLeasePaymentsUnderOperatingLeasesDetails" id="ScheduleOfFutureLeasePaymentsUnderOperatingLeasesDetails">
          <link:definition>999066 - Disclosure - SCHEDULE OF FUTURE LEASE PAYMENTS UNDER OPERATING LEASES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://harrow.com/role/ScheduleOfStockOptionPlanActivityDetails" id="ScheduleOfStockOptionPlanActivityDetails">
          <link:definition>999067 - Disclosure - SCHEDULE OF STOCK OPTION PLAN ACTIVITY (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://harrow.com/role/ScheduleOfFairValueAssumptionsDetails" id="ScheduleOfFairValueAssumptionsDetails">
          <link:definition>999068 - Disclosure - SCHEDULE OF FAIR VALUE ASSUMPTIONS (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:definition>999069 - Disclosure - SCHEDULE OF STOCK OPTION OUTSTANDING AND EXERCISABLE (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:definition>999070 - Disclosure - SCHEDULE OF RESTRICTED STOCK UNITS ACTIVITY (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:definition>999071 - Disclosure - SCHEDULE OF PERFORMANCE STOCK UNITS (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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        <link:roleType roleURI="http://harrow.com/role/ScheduleOfPerformanceStockUnitsActivityDetails" id="ScheduleOfPerformanceStockUnitsActivityDetails">
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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:definition>999073 - Disclosure - SCHEDULE OF STOCK BASED COMPENSATION GRANTED TO EMPLOYEES, DIRECTORS AND CONSULTANTS (Details)</link:definition>
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          <link:definition>999074 - Disclosure - STOCKHOLDERS&#8217; EQUITY AND STOCK-BASED COMPENSATION (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:definition>999075 - Disclosure - COMMITMENTS AND CONTINGENCIES (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:definition>999076 - Disclosure - SCHEDULE OF SEGMENT NET REVENUES (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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        <link:roleType roleURI="http://harrow.com/role/ScheduleOfRevenuesBySegmentDetails" id="ScheduleOfRevenuesBySegmentDetails">
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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:usedOn>link:calculationLink</link:usedOn>
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    <element id="HROW_ReportableSegmentAggregationResearchAndDevelopmentMember" name="ReportableSegmentAggregationResearchAndDevelopmentMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_IHEEZOMember" name="IHEEZOMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_VEVYEMember" name="VEVYEMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_OtherProductsMember" name="OtherProductsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_OtherRevenueMember" name="OtherRevenueMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_ImprimisRxMember" name="ImprimisRxMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_AccruedRebatesAndCopayAssistance" name="AccruedRebatesAndCopayAssistance" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_NoncashLeaseExpense" name="NoncashLeaseExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_PurchaseOfProductRightsAndRelatedPatents" name="PurchaseOfProductRightsAndRelatedPatents" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_PaymentOfPayrollTaxesUponVestingOfPsusRsusAndExerciseOfStockOptions" name="PaymentOfPayrollTaxesUponVestingOfPsusRsusAndExerciseOfStockOptions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_PurchaseOfProductAssociatedWithContingentConsiderationPayable" name="PurchaseOfProductAssociatedWithContingentConsiderationPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_DisclosureCapitalizedSoftwareCostsAbstract" name="DisclosureCapitalizedSoftwareCostsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_CapitalizedSoftwareCostsTextBlock" name="CapitalizedSoftwareCostsTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_DisclosureLeasesAbstract" name="DisclosureLeasesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_RisksUncertaintiesAndLiquidityPolicyTextBlock" name="RisksUncertaintiesAndLiquidityPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_ScheduleOfValuationAndQualifyingAccountsDisclosureTableTextBlock" name="ScheduleOfValuationAndQualifyingAccountsDisclosureTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_CapitalizedSoftwareDevelopmentCostsTableTextBlock" name="CapitalizedSoftwareDevelopmentCostsTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_ScheduleOfSegmentReportingInformationTextBlock" name="ScheduleOfSegmentReportingInformationTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_ConsolidationBasisDescription" name="ConsolidationBasisDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_GainLossOnValuationAllowancesAndReservesBalance" name="GainLossOnValuationAllowancesAndReservesBalance" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_PrepaidComputerSoftwareLicensesAndRelatedExpenses" name="PrepaidComputerSoftwareLicensesAndRelatedExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_PrefundedAssistance" name="PrefundedAssistance" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_ReceivableDueFromRelatedParty" name="ReceivableDueFromRelatedParty" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_PrepaidPrescriptionDrugUserFees" name="PrepaidPrescriptionDrugUserFees" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_ComputerHardwareGross" name="ComputerHardwareGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_FiniteLivedIntangibleAssetsDisposal" name="FiniteLivedIntangibleAssetsDisposal" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour" name="FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_LongTermNotesPayableGross" name="LongTermNotesPayableGross" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_NotesPayableCurrentGross" name="NotesPayableCurrentGross" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearThree" name="LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearThree" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_UnusedFeeRate" name="UnusedFeeRate" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_UnaccruedExitFee" name="UnaccruedExitFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_UnaccruedInterest" name="UnaccruedInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_LeaseLineItems" name="LeaseLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_LeaseExpirationDateDescription" name="LeaseExpirationDateDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" name="LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_AddtionalSharesPaidForTaxWithholdingForShareBasedCompensation" name="AddtionalSharesPaidForTaxWithholdingForShareBasedCompensation" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureFactor" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureFactor" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_SharebasedCompensationArrangementBySharebasedPaymentAwardDerivedServicePeriod" name="SharebasedCompensationArrangementBySharebasedPaymentAwardDerivedServicePeriod" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_DescriptionOfLicensesAgreements" name="DescriptionOfLicensesAgreements" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_UpfrontAndMilestonePayments" name="UpfrontAndMilestonePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_AaggregateAmountInCash" name="AaggregateAmountInCash" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_AnnualNetSalesMilestones" name="AnnualNetSalesMilestones" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_TotalAnnualNetSalesMilestones" name="TotalAnnualNetSalesMilestones" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="HROW_SubsequentEventsTable" name="SubsequentEventsTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
</schema>
